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Heart inflammation risk boosted slightly by vaccine but more by COVID

The use of Pfizer’s widely used COVID-19 vaccine marginally increases the risk of heart inflammation, particularly among young men, but the risk is much lower than among those infected with the coronavirus, a study published in the New England Journal of Medicine showed.

Among every 100,000 patients who get the vaccine, one to five will most likely develop myocarditis who would not otherwise have developed it, researchers reported, based on data from Clalit Health Services, a large Israeli health organisation.

A large study in Israel confirmed an earlier report of an increased risk in myocarditis among people who received the Pfizer vaccine.

A large study in Israel confirmed an earlier report of an increased risk in myocarditis among people who received the Pfizer vaccine.Credit:AP

That rate is much higher – 11 per 100,000 – among people infected with the virus, they said.

The data comes days after Pfizer/BioNTech’s COVID-19 vaccine became the first fully approved vaccine in the United States for people aged 16 and older, a move that could potentially persuade vaccine sceptics to get the shot.

The researchers compared adverse event rates in 884,828 vaccinated individuals and an equal number of unvaccinated people. Overall, 21 people reported myocarditis in the vaccinated group – mostly young men – compared with six people among the unvaccinated.

Most adverse events in vaccinated people were mild, but some, such as myocarditis, were potentially serious, researchers said.

The researchers also analysed adverse event rates in more than 240,000 infected patients. The results indicate that COVID-19 infection is itself a very strong risk factor for myocarditis, and it also substantially increases the risk of other serious adverse events, they said.

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“For me this is a really terrific paper in part because it actually takes data from the same system, and tries to provide more information, not just about the potential risks of vaccination, but also the potential benefits of vaccination,” said Dr Grace Lee of Stanford University, whose editorial was published with the report.

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